![]() Hypodypsia, an abnormally decreased amount of fluid intake, by the rat, due to possible hypothalamic space-occupying lesions.Excessive excretion of very dilute urine.Excessive thirst (need to refill water bottles more than usual).Lactation (ejection of milk) in aged non-pregnant female.Clinical signs and death may seem sudden to the owner even though manifestation is often gradual.A behavioral change (e.g., becomes aggressive).It is more often seen late in the disease process, and by itself should not be the basis for diagnosis of pituitary tumor! *Note: this sign should not be confused with normal attention-getting behavior. This sign may be present when there is increased intracranial pressure (rat may bump head up when petted, or extend head pressing against a fixed surface). Circling, head tilt, seizures, hydrocephalus.Blindness as a result of optic nerve compression.This may appear as blown/dilated pupil due to pressure or bleeding behind the eye. Unequal pupil size in one eye compared to the other.Stiffness or inability to flex forelimbs that may gradually progress to the hind limbs as the tumor continues to grow.Gradual weakness hind limbs, wide-based stance, knuckling, stumbling.Ataxia (lack of coordinated movement in limbs) with normal muscle strength. ![]() May see any combination of the following: Mechanical disturbances Pituitary tumor: an abnormal growth in the pituitary gland, the part of the brain that regulates the body’s balance of hormones. ![]()
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